Indication and Important Safety Information

Important Safety Information

Contraindications: MACI is contraindicated in patients with a known history of hypersensitivity to gentamicin, other aminoglycosides, products of porcine or bovine origin; in patients with severe osteoarthritis of the knee, inflammatory arthritis, inflammatory joint disease, or uncorrected congenital blood coagulation disorders; in patients who have undergone prior knee surgery in the past 6 months, excluding surgery to procure a biopsy or a concomitant procedure to prepare the knee for a MACI implant; or in patients unable to cooperate with a physician-prescribed post-surgical rehabilitation program.

Warnings and Precautions:
  • Malignancy: The risk of MACI in patients with malignancy in the area of cartilage biopsy or implant is unknown. Expansion of malignant or dysplastic cells present in biopsy tissue during manufacture and subsequent implantation may be possible.
  • Transmissible infectious diseases: Because patients undergoing procedures associated with MACI are not routinely tested for transmissible infectious diseases, cartilage biopsy and MACI implant may carry risk of transmitting infectious diseases.
  • Presurgical Comorbidities: Local inflammation or active infection in the bone, joint, and surrounding soft tissue, meniscal pathology, cruciate ligament instability, and misalignment should be assessed and treated prior to or concurrent with MACI implantation.
  • Product Sterility: Final sterility test results are not available at the time of shipping.

Adverse Reactions: The most frequently occurring adverse reactions reported for MACI (≥5%) were arthralgia, tendonitis, back pain, joint swelling, and joint effusion. Serious adverse reactions reported for MACI were arthralgia, cartilage injury, meniscus injury, treatment failure, and osteoarthritis.

Specific Populations:
  • Use of MACI in pediatric patients (younger than 18 years of age) or in patients over 65 years of age has not been established.
  • The MACI implant is not recommended during pregnancy. For implantations post-pregnancy, the safety of breastfeeding to an infant has not been determined.

To report negative side effects, contact Vericel Corporation at 1-800-453-6948 or FDA at 1-800-FDA-1088 (1-800-332-1088) or www.fda.gov/medwatch.

Please see Full Prescribing Information.

Indication

MACI® is an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or without bone involvement in adults.

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or without bone involvement in adults.

Limitations of Use

Effectiveness of MACI in joints other than the knee has not been established.

Safety and effectiveness of MACI in patients over the age of 55 years have not been established.

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MACI Arthro Simulated Hands-On Lab at AAOS.

March 13, 2025 05:30 PM PDT

San Diego, CA

Register Now

About the Program

Join us for an Educational Presentation and Simulated Hands-On Lab – MACI Arthro: An Arthroscopic Delivery Option

Arthroscopic delivery of MACI is for lesions ≤4 cm2 accessible using an arthroscopic approach.

This program is sponsored by Vericel Corporation and is not eligible for CME credits.

Featured Presenters

Grant H. Garcia, MD

Grant H. Garcia, MD

Proliance Sports & Shoulder Surgeon, Orthopedic Specialists of Seattle

Grant H. Garcia, MD, is an Orthopedic Sports and Shoulder Surgeon with Orthopedic Specialists of Seattle, and he provides services as a Team Physician for several athletic organizations, including Swim America. Moreover, he is a Reviewer for the Journal of Shoulder and Elbow Surgery, the American Journal of Sports Medicine, and Orthopedics.
Deryk Jones, MD

Deryk Jones, MD

Ochsner Sports Medicine Institute

Deryk G. Jones, MD, is the Chief of the Section of Sports Medicine and Cartilage Restoration at the Ochsner Sports Medicine Center, and he is a Professor at the University of Queensland School of Medicine. He is also an Adjunct Professor in the Department of Biomedical Engineering at Tulane University, where he serves as a Clinical Assistant Professor for the Department of Orthopedic Surgery at Tulane University School of Medicine.

Speakers are paid consultants of Vericel Corporation.

Venue

Roy's Restaurant
333 West Harbor Drive, San Diego, CA 92101